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If their destruction exceeds a certain extent, the beta cells can no longer produce the glucose-lowering hormone insulin, and the metabolism gets out of control. Third party content and cookies e. In this way, activation of T-cells may be induced or slowed down, which could be used for improved management of acute or chronic infections, improved results from vaccination or prevention of autoimmune diseases. We only use this information for improving our services. Different immune cells are therefore constantly in search of foreign molecules indicating the presence of any pathogen which needs to be destroyed. We need cookies to continuously improve the services, to enable certain features and when embedding services or content of third parties, such as video player. By using our website, you agree to the use of cookies. The large adhesion molecules accumulate around them in an outer ring. HZI researchers have investigated the formation of immunological synapses over which immune cells exchange information The immune system protects the human body against pathogens thus keeping it healthy.

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  • Press Release – Helmholtz Zentrum München
  • Meet the scientist — Bernstein Netzwerk Computational Neuroscience

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    In these models, they simulated different conditions and influencing factors and were able to demonstrate that the different molecules exert an influence on each other in terms of their arrangement although they do not interact directly.

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    Statistical cookies Matomo Permit cookies that help us to analyse the page views and user behavior on our websites. Both cells form a ring-shaped structure made of different proteins at the point of contact between the cells — termed immunological synapse — over which they can exchange information. Microscope image shows an immunological synapse.

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    From a medical point of view, these results are of particular significance for the area of treatment of defective T-cell activity.

    This cell type is responsible for classifying the presented parts as dangerous or harmless and, if necessary, initiating a response against them. As a next step, Semb and his team found new ways to specifically promote the proliferation of these beta cell precursors.

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    To achieve this, however, immune cells must be able to recognise intruders and to classify them as dangerous or harmless. Imprint De utsch En glish. If one of these cells meets a foreign body, it will integrate parts from it — called antigens — onto its own cell surface and present these to other immune cells: We use cookies to improve your experience on our Website.

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    As a next step, Semb and his team found new ways to specifically promote the proliferation of these beta cell precursors. The T-cell makes contact with the antigen-presenting cell by means of specialized adhesion molecules which initially are randomly distributed over the cell surface.

    Meet the scientist — Bernstein Netzwerk Computational Neuroscience

    You can personalize your cookie settings here: At the end of this process the T-cell is either activated or remains inactive. You can personalize your cookie settings here:. HZI researchers have investigated the formation of immunological synapses over which immune cells exchange information The immune system protects the human body against pathogens thus keeping it healthy.

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    Today, the researchers have published their results in the scientific journal Cell Reports. Robert, Philippos Demetriou, Michael L.

    images dating apps 2014 berlin

    In this way, activation of T-cells may be induced or slowed down, which could be used for improved management of acute or chronic infections, improved results from vaccination or prevention of autoimmune diseases. By using our website, you agree to the use of cookies.

    Both cells form a ring-shaped structure made of different proteins at the point of contact between the cells — termed immunological synapse — over which they can exchange information. Computer simulation of an immunological synapse with its characteristic ring-shaped structure.

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    1. Both cells form a ring-shaped structure made of different proteins at the point of contact between the cells — termed immunological synapse — over which they can exchange information. To achieve this, however, immune cells must be able to recognise intruders and to classify them as dangerous or harmless.

    2. They organise themselves in small clusters which are transported by actin in the direction of the centre of the synapse.

    3. Vimeo, Twitter, Googlemaps Permit embedded content and cookies from third party providers. They organise themselves in small clusters which are transported by actin in the direction of the centre of the synapse.